This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. If you drink more than 2 alcoholic beverages daily. To make sure simvastatin is safe for you, tell your doctor if you have: Heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil. HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.īefore you start taking simvastatin, tell your doctor if you are already using any of these other medicines: Hepatitis C medications - boceprevir, telaprevir or These drugs should not be used while you are taking this medicine:Īn antibiotic - clarithromycin, erythromycin, telithromycin Īntifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. You should not take this medicine if you are allergic to simvastatin, or if: Stop taking this medication and tell your doctor right away if you become pregnant. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS. Some medicines can cause unwanted or dangerous effects when used with simvastatin. Do not consume grapefruit products while taking this medication. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not use if you are pregnant or planning to become pregnant. Simvastatin can harm an unborn baby or cause birth defects. Taking too much of this medication may cause serious or life-threatening side effects.īefore taking this medicine, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily. Follow your doctor's dosing instructions very carefully. Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Simvastatin is used in adults and children who are at least 10 years old. Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors. Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Research is uncovering upsides of taking it for a variety of conditions, and we’ll likely see more to come, but it’s also on us to recognize that this is an unfolding story and proceed with caution.Medically reviewed by Sanjai Sinha, MD. With so much fanfare, it’s easy to ignore the fact that CBD is a potent compound that's far from exhaustively understood. The market for CBD products is predicted to pass $22 billion over the next four years, and that's coming with the expected hurricane of fact-obscuring hype. And it’s important to check with your doctor before taking CBD, especially if you’re taking other medications. But since the compound appears to exert similar effects as grapefruit, caution is needed.Īt a minimum, the evidence at this point suggests that grapefruit warnings on medications should also apply to CBD. One of the big problems with CBD at the moment is we don’t really know yet which drugs are affected the most, and it’s difficult to identify exact levels of risk because the research has a lot of catching up to do after decades of science-blocking illegality. Drugs with a narrow “therapeutic window” (they must stay within a certain blood-concentration range) are especially susceptible. A high dose of a med could become a dangerously high dose, or even an overdose. The enzymes that both grapefruit and CBD inhibit are thought to break down a significant percentage of prescription and over-the-counter medications, so the potential for problems could be high.Ī low dose of a med could become a high dose if it’s not properly broken down and eliminated.
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